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馬偕學校財團法人

重要著作

 

研究內容

陳裕仁醫師為放射腫瘤科醫師，專長著重於放射腫瘤學研究，申請人的研究成果，以臨床重點及問題為導向，結合抗癌藥物開發與放射治療基礎研究，包括：開發天然物中具臨床開發潛力之抗癌活性成分、分子醫學抗癌機制如癌症幹細胞訊息傳遞路徑、轉譯醫學研究、輻射增敏劑開發，臨床放射腫瘤研究，及臨床新技術開發等皆有涉獵，其研究早期著重在急性白血病、肝癌、大腸直腸癌等癌症的藥物開發及機制探討，近幾年除了持續研究上述癌症外，針對目前臨床尚未有良好有效藥物之胰臟癌、食道癌進行藥物及輻射增敏劑開發，另外也針對癌症幹細胞及其訊息傳遞路徑進行研究，茲將學術重要研究成就及發展之具體貢獻簡述如下：

  1. 放射增敏劑的開發及藥理研究模式

放射線對腫瘤細胞造成其DNA斷裂，活化DNA修復系統，為了抵抗此修復系統，臨床上發現，對放射線治療具有抗性的腫瘤細胞，其修補DNA雙股斷裂的能力也越好。因此增加癌細胞的輻射敏感度而達到放射治療的目的，在臨床上為常用的策略，輻射增敏劑(radioseasitizer)開發目的即抑制DNA修復系統，或是抑制細胞增值進而使腫瘤細胞走向凋亡途徑。到目前為此，臨床上所運用的輻射增敏劑不是效果不大，或是有增敏效果，但對身體正常組織或細胞常具有嚴重傷害。本人利用活體外及活體內之放射治療研究模式，包括利用Linear-Quadratic model 評估 Sensitizer enhancement ratio 及可同時評估效果及副作用之動物模式，並已利用此藥理研究模式，發現各種具活性之輻射增敏劑，以期對具放射治療抗性之腫瘤細胞具有加乘作用，並對正常組織或細胞具有保護效果。這些放射增敏劑包括：Caffeic acid phenethyl ester (CAPE)、resveratrol、tetrandrine、colchicine 等多種從天然物中萃取出的小分子化合物。例如：tetrandrine可使人類神經膠母細胞瘤(glioblastoma)增加輻射感受性；CAPE可使人類肺癌細胞A549或小鼠大腸直腸癌細胞CT26增加輻射感受性；秋水仙素可使人類肝癌細胞HA22T/VGH增加輻射感受性；白蔾蘆醇除了在非小細胞肺癌NCI-H838細胞可當輻射增敏劑外，也可抑制細胞的NF-kB的活化；奈米金粒子在小鼠的大腸直腸癌細胞CT26及乳癌細胞EMT-6發現具有輻射增敏效果；臨床上常用的化學抗癌藥物oxiliplatin，藉由調控兩種人類子宮頸癌細胞Hela及SiHa細胞內的DNA修復系統蛋白的表現，而達到輻射增敏的效果。

  1. 開發天然物中具專利潛力之抗癌活性成分並進行抗腫瘤機制探討

自天然物中純化具生化活性的小分子化合物並研究它們的抗癌機轉，這些天然物萃取分子包括：(馬偕一號)MMH01, CAPE、tetrandrine、platonin、Gold nanoparticle、norcantharidin、andrographolide、plumbagin等多種小分子化合物，其透過細胞內氧化還原態的不平衡、細胞凋亡、抑制血管新生、抑制腫瘤轉移或細胞自噬等不同機制而達到抗癌，並利用動物模式研究抗癌藥物的藥物動力學。

  1. 細胞死亡之多模式研究平台

細胞死亡模式不止apoptosis及necrosis，尚包括 mitotic catastrophe 及autophagy 等。本人致力於同時評估多種死亡模式之研究平台，並已提供研究人員使用之，除此之外，並已發表各相關論文及申請國內外藥物專利中，包含馬偕一號(MMH01)及馬偕二號(MMH02)等，其中馬偕一號(MMH01)已獲得美國專利，馬偕一號(MMH01)中華民國專利正在審查中。

  1. 癌症幹細胞訊息傳導路徑評估

癌症幹細胞 (Cancer stem cell) 已知是目前引起對癌症治療失敗且導致復發之主因。在癌症幹細胞訊息傳導中，超音速刺蝟狀(Sonic Hedgehog，簡稱SHH)訊息傳遞路徑的活化已知可能牽涉到放射線治療後腫瘤之增生或復發。SHH分子為分泌性訊息蛋白並最先在果蠅中發現。胚胎發育過程中SHH訊息傳遞路徑可調控各種形式的幹細胞之增生與分化，此路徑最終活化Gli轉錄蛋白家族，活化的Gli蛋白從細胞質移位到細胞核並活化基因的轉錄。Gli1蛋白轉錄的標靶基因包含調控細胞週期、細胞黏連，訊息傳遞路徑、血管形成，及細胞凋零的基因。SHH訊息傳遞路徑可能在癌症放射治療後再復發扮演中樞的角色，本研究室以此為平台尋找可以抑制SHH訊息傳遞及癌細胞生長的標靶藥物，以增強癌症治療之效果 。

  1. 臨床放射腫瘤學研究

研究頭頸部癌症及子宮頸癌症之放射治療新技術，減少病患之副作用，並發表特殊技術報告於國際放射腫瘤學術研討會，提昇此類病患之生活品質，且結合臨床與實驗室，將臨床所遇到問題，以實驗室研究平台進行癌症之分子生物學研究，以細胞分子進行標靶治療藥物的開發，或是研究免疫系統內巨噬細胞、樹突細胞、及自然殺手細胞等三者的免疫調節機制，或是研究天然物對腫瘤細胞或樹突細胞分化的機制，以期應用在臨床上解決問題，並對基礎醫學的研究具有突破性的進展。

  1. 臨床新技術之跨領域開發

隨著科技精進，新穎影像設備及放射治療儀器之開發使得順形放射治療得以實現。雖然順形放射線治療已被廣為接受用於治療癌症，但是其執行中，包括電腦斷層設計、數位影像重組產生之射束眼(Beam’s eye view)以及實際標靶涵蓋度三者之關聯度仍然尚未令人滿意。因此，申請人與台北科技大學合作，整合現有新穎科技，包括即時影像工具、機器手臂控制系統及影像整合處理系統，與放射治療設備結合以達到可以即時監控確認放射標靶 (例如：腫瘤)之位置是否涵蓋於各放射線角度之射束眼中。藉由此科技整合達到上述成果，在放射治療上之重大突破，預期可以大幅改善臨床使用放射線治療腫瘤之不確定度。此合作成果目前申請台灣、美國、日本、歐盟四國專利。台灣申請發明專利：即時監測標靶位置之放射治療系統；日本發明專利申請：?????位置????????????????放射線治療????。

  1. 臨床抗癌藥物之藥物動力學研究

對於開發中或臨床使用中之抗癌藥物，利用活體方式進行藥物動力學探討，這些藥物包括了colchicine、cyclosporin A、doxorubucin、5-fluorouracil等，其中colchicine、cyclosporin A、doxorubucin的藥物動力學結果於2008年發表國際知名期刊Int J Pharmaceut；而5-fluorouracil藥物結合放射治療其藥物動力學結果顯示局部放射治療會影響化療藥物在體內的分佈，對於臨床同步放射化學治療癌症的效果需進一步周詳考慮，此研究成果發表在J Transl Med期刊(2010)；接著探討放射治療如何影響5-fluorouracil的分佈之機制，發現輻射照射後，透過活化MMP-8的表現而影響化療藥物的分佈，提出若同步放射化學治療，其化療藥物劑量需從新評估及調整，此重要研究成果發表在PLoS One期刊上(2011)。

 

發表論文著述：

 

    SCI papers

  1. Chu CM, Chi CW, Chang SC, Wang YC, Chiang CL, Hsieh SH, Chung HY, Chan YL, Huang CH, Chen YJ*. Enhancement of Swimming Endurance by Herbal Supplement DC-M3P. Chin J Integr Med. 2018 (accepted).
  1. Yang CY, Chen C, Lin CY, Chen YH, Lin CY, Chi CW, Chen YJ, Liu SC, Chang TK, Tang CH, Lai YW, Tsai HJ, Chen JJ, Wang SW. Garcimultiflorone K inhibits angiogenesis through Akt/eNOS- and mTOR-dependent pathways in human endothelial progenitor cells. Phytomedicine. 2019 (in press).
  1. Lee J, Lin JB, Wu MH, Jan YT, Chang CL, Huang CY, Sun FJ, Chen YJ*. Muscle radiodensity loss during cancer therapy is predictive for poor survival in advanced endometrial cancer. J Cachexia Sarcopeni. 2019 Aug; 10(4): 814-826.
  1. Hou TC, Dai KY, Wu MC, Hua KL, Tai HC, Huang WC, Chen YJ*. Bio-physic constraint model using spatial registration of delta 18F-fluorodeoxyglucose positron emission tomography/computed tomography images for predicting radiation pneumonitis in esophageal squamous cell carcinoma patients receiving neoadjuvant chemoradiation. OncoTargets Ther. 2019 Aug; 12: 6439-6451.
  1. Lin JB, Hung LC, Cheng CY, Chien YA, Lee CH, Huang CC, Chou TW, Ko MH, Lai YC, Liu MT, Chang TH, Lee J, Chen YJ. Prognostic significance of lung radiation dose in patients with esophageal cancer treated with neoadjuvant chemoradiotherapy. Radiat Oncol. 2019 May; 14(1): 8
  1. Liu SY, Huang WC, Yeh HI, Ko CC, Shieh HR, Hung CL, Chen TY, Chen YJ*. Sequential blockade of PD-1 and PD-L1 causes fulminant cardiotoxicity-from case report to mouse model validation. Cancers. 2019 Apr; 11(4): 580.
  1. Tai HC, Lee TH, Tang CH, Chen LP, Chen WC, Lee MS, Chen PC, Lin CY, Chi CW,Chen YJ, Lai CT, Chen SS, Liao KW, Lee CH, Wang SW. Phomaketide A Inhibits Lymphangiogenesis in Human Lymphatic Endothelial Cells. Mar Drugs. 2019 Apr; 17(4): 215.
  1. Chung IC, OuYang CN, Yuan SN, Lin HC, Huang KY, Wu PS, Lin CY, Tsai KJ, Loi LK, Chen YJ, Chung AK, Ojcius DM, Chang YS, Chen LC. Pretreatment with a heat-killed probiotic modulates the NLRP3 inflammasome and attenuates colitis-associated colorectal cancer in mice. Nutrients. 2019 Mar; 11: 516.
  1. Chen WK, Chen CA, Chi CW, Li LH, Lin CP, Shieh HR, Hsu ML, Ko CC, Hwang JJ, Chen YJ*. Moscatilin inhibits growth of human esophageal cancer xenograft and sensitizes cancer cells to radiotherapy. J Clin Med. 2019 Feb; 8: 187.
  1. Su NW, Wu SH, Chi CW, Tsai TH, Chen YJ*. Cordycepin, isolated from medicinal fungus Cordyceps sinensis, enhances radiosensitivity of oral cancer associated with modulation of DNA damage repair. Food Chem Toxicol. 2019 Feb 124: 400-4
  1. Lee J, Liu SH, Lin JB, Wu MH, Wu CJ, Tai HC, Hsu SM, Chen YJ, Tai JC, Chen YJ. Image-guided study of inter-fraction and intra-fraction set-up variability and margins in reverse semi-decubitus breast radiotherapy. Radiat Oncol. 2018 Dec; 13(1): 254.
  1. Chung IC, Yuan SN, OuYang CN, Lin HC, Huang KY, Chen YJ, Chung AK, Chu CL, Ojcius DM, Chang YS, Chen LC. Src-family kinase-Cbl axis negatively regulates NLRP3 inflammasome activation. Cell Death Dis. 2018 Oct; 9(11): 1109.
  1. Chiu CJ, Chi CW, Hsieh HR, Huang YC, Wu HJ, Chen YJ*. Modulation of macrophage polarization by level-1 Yo-Yo intermittent recovery test in young football players. Medicine. 2018 Oct; 97(42): e12739.
  1. Lee J, Chang CL, Lin JB, Wu MH, Sun FJ, Jan YT, Hsu SM, Chen YJ. Skeletal muscle loss is an imaging biomarker of outcome after definitive chemoradiotherapy for locally advanced cervical cancer. Clin Cancer Res. 2018 Oct; 24(20): 5028-5036.
  1. Chen HT, Wu HJ, Chen YJ, Ho SY, Chung YC. Effects of 8-week kettlebell training on body composition, muscle strength, pulmonary function, and chronic low-grade inflammation in elderly women with sarcopenia. Exp Gerontol. 2018 Oct; 112: 112-118.
  1. Lee MJ, Tseng WS, Lai JCY, Shieh HR, Chi CW, Chen YJ*. Differential pharmacological activities of oxygen numbers on sulfoxide moiety of wasabi compound 6-(Methylsulfinyl) hexyl isothiocyanate in human oral cancer cells. Molecules. 2018 Sep; 23(10): 2427.
  1. Lee J, Chang CL, Lin JB, Wu MH, Sun FJ, Wu CJ, Tai HC, Hsu SM, Chen YJ. The effect of body mass index and weight change on late gastrointestinal toxicity in locally advanced cervical cancer treated with intensity-modulated radiotherapy. Int J Gynecol Cancer. 2018 Sep; 28(7): 1377-1386.
  1. Liu YM, Liu YK, Huang PI, Tsai TH, Chen YJ*. Antrodia cinnamomea mycelial fermentation broth inhibits the epithelial-mesenchymal transition of human esophageal adenocarcinoma cancer cells. Food Chem Toxicol. 2018 Sep; 119: 380-386.
  1. Lin WC, Wang WH, Lin YH, Leu JD, Cheng SY, Chen YJ*, Hwang JJ. Synergistic effects of tetrandrine combined with ionizing radiation on a murine colorectal carcinoma?bearing mouse model. Oncol Rep. 2018 Sep; 40(3):1390-1400.
  1. Chen MJ, Wu IC, Chen YJ, Wang TE, Chang YF, Yang CL, Huang WC, Chang WK, Sheu BS, Wu MS, Lin JT, Chu CH. Nutrition therapy in esophageal cancer-Consensus statement of the Gastroenterological Society of Taiwan. Dis Esophagus. 2018 Aug; 31(8): 1-9.
  1. Chiang PK, Tsai WK, Chen M, Lin WR, Chow YC, Lee CC, Hsu JM, Chen YJ*. Zerumbone regulated DNA repair responding to ionizing radiation and enhances radiosensitivity of human prostatic cancer cells. Inteqr Cancer Ther. 2018 Jun; 17(2): 292-298.
  1. Lee J, Wu MH, Chen YJ*. Delineation guideline for the para-aortic lymph node region in cervical cancer. Radiother Oncol. 2018 May; S0167-8140(18): 30251-2.
  1. Chang CW, Liu CY, Lee HC, Huang YH, Li LH, Chiang Chiau JS, Wang TE, Chu CH, Shih SC, Tsai TH, Chen YJ*. Lactobacillus casei variety rhamnosus probiotic preventively attenuates 5-fluorouracil/oxaliplatin-induced intestinal injury in a syngeneic colorectal cancer model. Front Microbiol. 2018 May; 9: 983.
  1. Huang WC, KuoKT, Adebayo BO, Wang CH, Chen YJ, Lin K, Tsai TH, Yeh CT. Garcinol inhibits cancer stem-like phenotype via suppressor of the Wnt/b-catenin/STAT3 axis signalling pathway in human non-small cell lung carcinomas. J Nutr Biochem. 2018 Apr; 54: 140-150.
  1. Lee J, Lin JB, Chang CL, Sun FJ, Wu MH, Jan YT, Chen YJ*. Impact of para-aortic recurrence risk-guided intensity-modulated radiotherapy in locally advanced cervical cancer with positive pelvic lymph nodes. Gynecol Oncol. 2018 Feb; 148(2):291-298.
  1. Liu CK, Chen CA, LeeTY, Chang HH, Liao HF, Chen YJ*. Rice protein prolamin promotes anti-leukemia immunity and inhibits leukemia growth in vivo. Food Chem Toxicol. 2018 Feb; 112:435-440.
  1. Chen YJ, Tsai TH, Wang LY, Hsieh CH. Local radiotherapy affects drug pharmacokinetics-exploration of a neglected but significant uncertainty of cancer therapy. Technol Cancer Res T. 2017 Dec; 16(6):705-716.
  1. Shih CH, Chang YJ, Huang WC, Jang TH, Kung HJ, Wang WC, Yang MH, Lin MC, Huang SF, Chou SW, Chang E,Chiu H, Shieh TY, Chen YJ, Wang LH, Chen L. EZH2-mediated upregulation of ROS1 oncogene promotes oral cancer metastasis. Oncogene. 2017 Nov; 36(47): 6542-6554.
  1. Chen CA, Liu CK, Hsu ML, Chi CW, Ko CC, Chen JS, Lai CT, Chang HH, Lee TY, Lai YL, Chen YJ*. Daphnoretin modulates differentiation and maturation of human dendritic cells through down-regulation of c-Jun N-terminal kinase. Int Immunopharmacol. 2017 Oct; 51: 25-30.
  1. Chung LC, Chiang KC, Feng TH, Chang KS, Chuang ST, Chen YJ, Tsui KH, Lee JC, Juang HH. Caffeic acid phenethyl ester upregulates N-myc downstream regulated gene 1 via ERK pathway to inhibit human oral cancer cell growth in vitro and in vivo. Mol Nutr Food Res. 2017 Sep; 61(9).
  1. Lee J, Lin JB, Chang CL, Jan YT, Sun FJ, Wu MH, Chen YJ*. Prophylactic lower para-aortic irradiation using intensity-modulated radiotherapy mitigates the risk of para-aortic recurrence in locally advanced cervical cancer: A 10-year institutional experience. Gynecol Oncol. 2017 Jul; 146(1): 20-26.
  1. Chen HT, Chung YC, Chen YJ, Ho SY, Wu HJ. Effects of different types of exercise on body composition, muscle strength, and IGF-1 in the elderly with sarcopenic obesity. J Am Geriatr Soc. 2017 Apr; 65(4): 827-8
  1. Su NW, Wu, SH, Chi CW, Liu CJ, Tsai TH, Chen YJ*. Metronomic cordycepin therapy prolongs survival of oral cancer-bearing mice and inhibits epithelial-mesenchymal transition. Molecules. 2017 Apr; 21: 629.
  1. Lee J, Hua KL, Hsu SM, Lin JB, Lee CH, Lu KW, Dai KY, Huang XN, Huang JZ, Wu MH, Chen YJ*. Development of delineation for the left anterior descending coronary artery region in left breast cancer radiotherapy: An optimized organ at risk radiotherapy and oncology. Radiother Oncol. 2017 Mar 122(3): 423-430.
  1. Lee J, Lin JB, Sun FJ, Chen YJ, Chang CL, Jan YT, Wu MH. Safety and efficacy of semiextended field intensity-modulated radiation therapy and concurrent cisplatin in locally advanced cervical cancer patients: An observational study of 10-year experience. Medicine. 2017 Mar; 96 (10): e6158.
  1. Chen ST, Lee TY, Tsai TH, Lin YC, Lin CP, Shieh HR, Hsu ML, Chi CW, Lee MC, Chang HH, Chen YJ*. The traditional Chinese medicine DangguiBuxue Tang sensitizes colorectal cancer cells to chemoradiotherapy. Molecules. 2016 Dec; 21: 1677.
  1. Liu YM, Liu YK, Wang LW, Huang YC, Huang PI, Tsai TH, Chen YJ*. The medicinal fungus Antrodia cinnamomea regulates DNA repair and enhances the radiosensitivity of human esophageal cancer cells. OncoTargets Ther. 2016 Oct; 9: 6651-6661.
  1. Chiou CT, Shen CC, Tsai TH, Chen YJ, Lin LC. Meroterpenoids and chalcone-lignoids from the roots of Mimosa diplotricha. J Nat Pro. 2016 Oct; 79(10): 2439-2445.
  1. Chung IC, OuYang CN, Yuan SN, Li HP, Chen JT, Shieh HR, Chen YJ, Ojcius DM, Chu CL, Yu JS, Chang YS, Chen LC. Pyk2 activates the NLRP3 inflammasome by directly phosphorylating ASC and contributes to inflammasome-dependent peritonitis. Sci Rep-UK. 2016 Oct; 6: 36214.
  1. Lee J, Lin JB, Sun FJ, Lu KW, Lee CH, Chen YJ, Huang WC, Liu HC, Wu MH. Dosimetric predictors of acute haematological toxicity in oesophageal cancer patients treated with neoadjuvant chemoradiotherapy. Brit J Radiol. 2016 Oct; 89(1066): 20160350.
  1. Lee JC, Chiang KC, Feng TH, Chen YJ, Chuang ST, Tsui KH, Chung LC, Juang HH. The iron chelator, Dp44mT, effectively inhibits human oral squamous cell carcinoma cell growth in vitro and in vivo. Int J Mol Sci. 2016 Aug; 17(9): 1435.
  1. Chang MC, Wu JY, Liao HF, Chen YJ, Kuo CD. Comparative assessment of therapeutic safety of norcantharidin, N-farnesyloxy-norcantharimide, and N-farnesyl-norcantharimide against Jurkat T cells relative to human normal lymphoblast: a quantitative pilot study. Medicine. 2016 Aug; 95(31): e4467.
  1. Chen YJ, Chen CC, Huang HL. Induction of apoptosis by Armillaria mellea constituent armillarikin in human hepatocellualr carcinoma. OncoTargets Ther. 2016 Aug; 9: 4773-4783.
  1. Chen YJ, Fang LW, Su WC, Hsu WY, Yang KC, Huang HL. Lapatinib induces autophagic cell death and differentiation in acute myeloblastic leukemia. OncoTargets Ther. 2016 Jul; 9: 4453-4464.
  1. Huang YC, Chang HH, Chiu SC, Lai YL, Chen YJ*. Modified Dang Gui Liu Huang Tang eases sleep sweats in elderly patients with terminal cancer. Int J Gerontol. 2016 Jun; 10(2): 96-99.
  1. Hsieh CH, Lin YC, ChenYJ, Wu HD, Wang LY. Diaphragm contractile dysfunction causes by off-target low-dose irradiation. Am J Transl Res. 2016 Mar; 8(3): 1510-1517.
  1. Jan YT, Chang CL, Tai HC, Huang YC, Liao CL, Chen YJ*. The air matters – sleeve air cavity as a marker guiding image-guided helical tomotherapy to target cervical cancer. J Contemp Brachyther. 2016 Feb; 8(1): 82-87.
  1. Chang HH, Luo SF, Hsue YT, Chang CM, Lee TY, Huang YC, Hsu ML, Chen YJ*. Modulation of endothelial injury biomarkers by Traditional Chinese Medicine LC in systemic lupus erythematosus patients receiving standard treatments. Sci Rep-UK. 2016 Feb; 6:19622.
  1. Klionsky DJ, et al., Chen YJ, et al., Zughaier SM. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016 Jan; 12(1):1-222.
  1. Lai YW, Wang SW, Chang CH, Liu SC, Chen YJ, Chi CW, Chiu LP, Chen SS, Chiu AW, Chung CH. Butein inhibits metastatic behavior in mouse melanoma cells through VEGF expression and translation-dependent signaling pathway regulation. BMC Complem Altern M. 2015Dec; 15(1): 445.
  1. Chang MC, Wu JY, Liao HF, Chen YJ, Kuo CD. N-Farnesyloxy-norcantharimide inhibits progression of human leukemic Jurkat T cells through regulation of mitogen-activated protein kinase and interleukin-2 production. Anti-Cancer Drug. 2015 Nov; 26(10): 1034-1042.
  1. Hua KL, Hsu CH, Hidayati SC, Cheng WH, Chen YJ*. Computer-aided classification of lung nodules on computed tomography images via deep learning technique. OncoTargets Ther. 2015 Aug; 8: 2015-2022.
  1. Liu SH, Chao KS, Leu YS, Lee JC, Liu CJ, Huang YC, Chang YF, Chen HW, Tsai JT, Chen YJ*. Guideline and preliminary clinical practice results for dose specification and target delineation for postoperative radiotherapy of oral cavity cancer. Head Neck-J Sci Spec. 2015 Jul; 37(7):933-939.
  1. Chang MC, Tsai ET, Wu JY, Liao HF, Chen YJ, Kuo CD. N-Farnesyloxy-norcantharimide and N-farnesyl-norcantharimide inhibit the progression of leukemia and increase survival days in a syngeneic mouse leukemia model. Anti-Cancer Drug. 2015 Jun; 26(5): 508-517.
  1. Chang CH, Liu SY, Chi CW, Yu HL, Chang TJ, Tsai TH, Lee TW, Chen YJ*. External beam radiotherapy synergizes 188Re-liposome against human esophageal cancer xenograft and modulates 188Re-liposome pharmacokinetics. Int J Nanomed. 2015 May; 10: 3641-3649.
  1. Lee JC, Chung LC, Chen YJ, Feng TH, Chen WT, Juang HH. Upregulation of B-cell translocation gene 2 by epigallocatechin-3-gallate via p38 and ERK signaling blocks cell proliferation in human oral squamous cell carcinoma cells. Cancer Lett.2015 May; 360(2): 310-318.
  1. Hsieh CH, Hou ML, Wang LY, Tai HC, Tsai TH, Chen YJ*. Local pelvic irradiation modulates pharmacokinetics of 5-fluorouracil in the plasma but not in the lymphatic system. BMC Cancer. 2015 Apr; 15(1): 316.
  1. Liu TP, Chen CC, Shiao PY, Shieh HR, Chen YY, Chen YJ*. Armillaridin, a honey medicinal mushroom, Armillaria mellea (Higher Basidiomycetes) component, inhibits differentiation and activation of human macrophages. Int J Med Mushrooms. 2015 Mar-Apr; 17(2): 161-168.
  1. Chiang MF, Chen HH, Chi CW, Sze CI, Hsu ML, Shieh HR, Lin CP, Tsai JT, Chen YJ*. Modulation of Sonic hedgehog signaling and WW domain containing oxidoreductase WOX1 expression enhances radiosensitivity of human glioblastoma cells. Exp Biol Med. 2015 Mar; 240(3): 392-399.
  1. Liu SY, Chang MF, Chen YJ*. Role of WW domain proteins WWOX in development, prognosis, and treatment response of glioma. Exp Biol Med. 2015 Mar; 240(3): 315-323.
  1. Tsai TH, Chen YJ (Co-first author), Hou ML, Wang LY, Tai HC, Hsieh CH. Pelvic irradiation modulates the pharmacokinetics of cisplatin in the plasma and lymphatic system. Am J Transl Res. 2015 Feb; 7(2): 375-384.
  1. Su NW, Liu CJ, Leu YS, Lee JC, Chen YJ, Chang YF. Prolonged radiation time and low nadir hemoglobin during postoperative concurrent chemoradiotherapy are both poor prognostic factors with synergic effect on locally advanced head and neck cancer patients. OncoTargets Ther. 2015 Jan; 8: 251-258.
  1. Liu YK, Chen KH, Leu YL, Way TD, Wang LW, Chen YJ*, Liu YM. Ethanol extracts of Cinnamomum kanehirai Hayata leaves induce apoptosis in human hepatoma cell through caspase-3 cascade. OncoTargets Ther. 2015 Jan; 8: 99-109.
  1. Lee JC, Chung LC, Chen YJ, Feng TH, Juang HH. N-myc downstream-regulated gene 1 downregulates cell proliferation, invasiveness, and tumorigenesis in human oral squamous cell carcinoma. Cancer Lett. 2014 Dec; 355(2): 242-252.
  1. Su NW, Leu YS, Lee JC, Liu CJ, Cheng CY, Lin JS, Chen YJ, Chen CK, Fang IC, Hsieh RK, Chang YF. EGF and EGFR genetic polymorphisms predict prognosis in locally advanced pharyngolaryngeal squamous cell carcinoma patients receiving postoperative concurrent chemoradiotherapy. OncoTargets Ther. 2014 Nov; 7: 2197-2204.
  1. Chen YH, Lee YT, Wen CC, Chen YC, Chen YJ*. Modeling pegylated liposomal doxorubicin-induced hand-foot syndrome and intestinal mucositis in zebrafish. OncoTargets Ther. 2014 Jul; 7: 1169-1175.
  1. Chiang MF, Chen ST, Lo CP, Sze CI, Chang NS, Chen YJ*. Expression of WW domain-containing oxidoreductase WOX1 in human nervous system tumors. Anal Cell Pathol. 2014 Jun; 36(5-6): 133-147.
  1. Lee JC, Chang SH, Yang CC, Hsieh CH, Chen YJ*. Elderly patients with laryngeal and hypopharyngeal cancer undergoing total pharyngolaryngectomy with a radial forearm, free flap-reconstructed phonation tube. Int J Gerontol. 2014 Jun; 8(2): 85-89.
  1. Chang WC, Chen CS, Tai HC, Liu CY, Chen YJ*. Integration of multidisciplinary technologies for real time target visualization and verification for radiotherapy. OncoTargets Ther. 2014 Jun; 7: 1143-1150.
  1. Wu JY, Kuo CD, Chu CY, Chen MS, Lin JH, Chen YJ, Liao HF. Synthesis of novel lipophilic N-substituted norcantharimide derivatives and evaluation of their anticancer activities. Molecules. 2014 May; 19(6): 6911-6928.
  1. Chang WC, Chen CS, Liu CY, Chen YJ. Physician-commanded six-DOF robotic manipulation for target localization in conformal radiotherapy. Asian J Control. 2014 May; 16(3): 795-801.
  1. Hsieh CH, Shueng PW, Wang LY, Liao LJ, Lin YC, Kuo YS, Lo WC, Tseng CF, Tien HJ, Chou HL, Hsieh YP, Wu LJ, Chen YJ*. Clinical effectiveness, toxicity, and failure patterns of helical tomotherapy for postoperative oral cavity cancer patients. OncoTargets Ther. 2014 Mar; 7: 405-414.
  1. Huang YC, Yang YC, Yang KC, Shieh HR, Wang TY, Hwu Y, Chen YJ*. Pegylated gold nanoparticles induce apoptosis in human chronic myeloid leukemia cells. BioMed Res Int. 2014 Feb; 2014: ID 182353.
  1. Chen YJ, Wu SY, Chen CC, Tsao YL, Hsu NC, Chou YC, Huang HL. Armillaria mellea component armillarikin induces apoptosis in human leukemia cells. J Funct Foods. 2014 Jan; 6: 196-204.
  1. Chen YJ, Huang YC, Tsai TH, Liao HF. Effect of wasabi component 6-(methylsulfinyl)hexyl isothiocyanate and derivatives on human pancreatic cancer cells. Evid-Based Compl Alt. 2014 Jan; 2014 ID: 494739.
  1. Yeh CT, Huang WC, Rao YK, Ye M, Lee WH, Wang LS, Tzeng DT, Wu CH, Shieh YS, Huang CY, Chen YJ, Hsiao M, Wu AT, Yang Z, Tzeng YM. A sesquiterpene lactone antrocin from Antrodia camphorata negatively modulates JAK2/STAT3 signaling via microRNA let-7c and induces apoptosis in lung cancer cells. Carcinogenesis. 2013 Dec; 34(12): 2918-2928.
  1. Liu HC, Huang WC, Wu CL, Huang JT, Chen CH, Chen YJ (Co-first author). Surgery for elderly lung cancer. Ann Thorac Cardiovas. 2013 Dec; 19(6): 416-422.
  1. Chen CA, Chen CC, Shen CC, Chang HH, Chen YJ*. Moscatilin induces apoptosis and mitotic catastrophe in human esophageal cancer cells. J Med Food. 2013 Oct; 16(10): 869-877.
  1. Huang YC, Jiang CM, Chen YJ*, Chen YY. Pectinesterase inhibitor from jelly fig (Ficus awkeotsang Makino) achene inhibits surface antigen expression by human hepatitis B virus. Evid-Based Compl Alt. 2013 Oct; 2013: ID 434828.
  1. Lin CC, Liu CY, Chen MJ, Wang TE, Chu CH, Wang HY, Shih SC, Hsu ML, Hsu TC, Chen YJ*. Profiles of circulating endothelial cells and serum cytokines during adjuvant chemoradiation in rectal cancer patients. Clin Transl Oncol. 2013 Oct; 15(10): 855-860.
  1. Liu HC, Chen YJ. Lu YC, Wu CL, Huang WC, Huang JT. Monitoring apnea in the elderly by an electromechanical system with a carbon nanotube-based sensor. Int J Gerontol. 2014 Sep; 7(3): 147-151.
  1. Hiseh CH, Chao KSC, Liao HF, Chen YJ*. Norcantharidin, derivative of cantharidin, for cancer stem cells. Evid-Based Compl Alt. 2013 Sep; 2013: ID 838651.
  1. Chen MJ, Wang TE, Tsai SJ, Lin CC, Liu CY, Wang HY, Shih SC, Chen YJ*. Oral glutamine supplement inhibits ascites formation in peritoneal carcinomatosis mouse model. Gastroent Res Pract. 2013 Sep; 2013: ID 814054.
  1. Hsieh CH, Hou ML, Chiang MH, Tai HC, Tien HJ, Wang LY, Tsai TH, Chen YJ*. Head and neck irradiation modulates pharmacokinetics of 5-fluorouracil and cisplatin. J Transl Med. 2013 Sep; 11(1): 231.
  1. Hsieh CH, Shueng PW, Lin SC, Tien HJ, Shiau AC, Chou YH, Wu MH, Wang JY, Chen CK, Chen YJ. Helical irradiation of the total skin with dose painting to replace total skin electron beam therapy for therapy-refractory cutaneous CD4+ T-cell lymphoma. BioMed Res Int. 2013 Sep; 2013: ID 717589.
  1. Liu HC, Huang WC, Chen YJ, Lu CC, Huang JT. An electromechanical system based on carbon nanotube sensors to detect apnea. IEEE Sens J. 2013 Jul; 13(7): 2737-2741.
  1. Liao HF, Chao KS, Chen YJ, Chang MS. Complementary and alternative medicine in cancer stem cells. Evid-Based Compl Alt. 2013 Jun; 2013 ID: 560274.
  1. Chi CW, Chen CC, Chen YJ*. Therapeutic and radiosensitizing effects of amillaridin on human esophageal cancer cells. Evid-Based Compl Alt. 2013 May; 2013 ID: 459271.
  1. Chen YJ, Chen YY, Lin YF, Hu HY, Liao HF. Resveratrol inhibits alpha-melanocyte-stimulating hormone signaling, viability, and invasiveness in melanoma cells. Evid-Based Compl Alt. 2013 May; 2013 ID: 632121.
  1. Huang YC, Chao KSC, Liao HF, Chen YJ*. Targeting sonic hedgehog signaling by compounds and derivatives from natural products. Evid-Based Compl Alt. 2013 May; 2013 ID: 748587.
  1. Chen MJ, Shih SC, Wang HY, Lin CC, Liu CY, Wang TE, Chu CH, Chen YJ*. Caffeic acid phenethyl ester inhibits epithelial-mesenchymal transition of human pancreatic cancer cells. Evid-Based Compl Alt. 2013 Apr; 2013 ID: 270906.
  1. Lin JC, Huang WP, Liu CL, Lee JJ, Liu TP, Ko WC, Huang YC, Hsu ML, Wu CH, Chen YJ*. Sorafenib induces autophagy in human myeloid dendritic cells and prolongs survival of skin allografts. Transplantation. 2013 Mar; 96(6): 791-800.
  1. Huang WC, Huang CH, Hsu HS, Hsieh CC, Hsu WH, Tsia TH, Chen YJ*. Intrathoracic goiter in elderly patients. Int J Gerontol. 2013 Mar; 7(1): 8-12.
  1. Hsieh KC, Chen YJ (Co-first author), Lu HK, Lee LC, Huang YC, Chen YY. The novel application of artificial neural network on bioelectrical impedance analysis to assess the body composition in elderly. Nutr J. 2013 Feb; 12: 21.
  1. Hsieh CH, Tien HJ, Hsiao SM, Wei MC, Wu WY, Sun HD, Wang LY, Hsieh YP, Chen YJ, Shueng PW. Stereotactic body radiation therapy via helical tomotherapy to replace brachytherapy for brachytherapy-unsuitable cervical cancer patients- a preliminary result. OncoTargets Ther. 2013 Feb; 6: 59-66.
  1. Lin JC, Liu CL, Lee JJ, Liu TP, Ko WC, Huang YC, Wu CH, Chen YJ*. Sorafenib induces autophagy and suppresses activation of human macrophage. Int Immunopharmacol. 2013 Feb; 15(2): 333-339.
  1. Liu YM, Liu YK, Lan KL, Lee YW, Tsai TH, Chen YJ*. Medicinal fungus Antrodia cinnamomea inhibits growth and cancer stem cell characteristics of hepatocellular carcinoma. Evid-Based Compl Alt. 2013 Jan; 2013 ID: 569737.
  1. Wang YF, Chang CJ. Lin CP, Chang SY, Chu PY, Tai SK, Li WY, Chao KS, Chen YJ*. Expression of hedgehog signaling molecules as a prognostic indicator of oral squamous cell carcinoma. Head Neck- J Sci Spec. 2012 Nov 34(11): 1556-1561.
  1. Liu CY, Tsai TH, Huang YC, Shieh HR, Liao HF, Chen YJ*. Differential immunomodulating effects of pegylated liposomal doxorubicin nanoparticles on human macrophages. J Nanosci Nanotechno. 2012 Oct 12(10): 7739-7746.
  1. Lee CY, Fang CK, Yang YC, Liu CL, Leu YS, Wang TE, Chang YF, Hsieh RK, Chen YJ, Tsai LY, Liu SI, Chen HW. Demoralization syndrome among cancer outpatients in Taiwan. Support Care Cancer. 2012 Oct; 20(10): 2259-2267.
  1. Chiang MF, Yeh ST, Liao HF, Chang NS, Chen YJ*. Overexpression of WW domain-containing oxidoreductase WOX1 preferentially induces apoptosis in human glioblastoma cells harboring mutant p53. Biomed Pharmacother. 2012 Sep; 66(6): 433-438.
  1. Liu CY, Yang PS, Cheng SP, Huang YC, Lee JJ, Ko CC, Shieh HR, Chen YJ*. Zoledronic acid, an aminobisphosphonate, prolongs survival of skin allografts. Clin Invest Med. 2012 Aug; 35(4): E165-E172.
  1. Liao HF, Su YC, Zheng ZY, Chang JC, Hou MH, Chao KSC, Chen YJ*. Sonic hedgehog signaling regulates Bcr-Abl expression in human chronic myeloid leukemia cells. Biomed & Pharmacother. 2012 Jul; 66(5): 378-383.
  1. Liao HF, Cheng AJ, Huang HT, Shen ML, Hei TK, Chen YJ*. Nuclear factor-kappaB as a switch in regulation of resveratrol-mediated apoptosis and erythrocytic differentiation in human leukemia cells. Food Chem. 2012 Jun 132(4): 2094-2101.
  1. Chen YJ, Kuo CD, Chen SH, Chen WJ, Huang WC, Chao KS, Liao HF. Small-molecule synthetic compound norcantharidin reverses multi-drug resistance by regulating sonic hedgehog signaling in human breast cancer cells. PLoS One. 2012 May; 7(5): e37006.
  1. Klionsky DJ, et al., Chen YJ, et al., Zuckerbraun B. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4): 445-544.
  1. Chen HW, Lin IH, Chen YJ, Chang KH, Wu MH, Su WH, Huang GC, Lai YL. A novel infusible botanically –derived drug, PG2, for cancer-related fatigue: A phase II double-blind, randomized placebo-controlled study. Clin Invest Med. 2012 Feb 35(1): E1-E11.
  1. Huang HL, Chen YC, Huang YC, Yang KC, Pan HY, Shih SP, Chen YJ*. Lapatinib induces autophagy, apoptosis and megakaryocytic differentiation in chronic myelogenous leukemia K562 cells. PLoS One. 2011 Dec; 6(12): e29014.
  1. Lin YS, Huang LD, Lin CH, Huang PH, Chen YJ, Wong FH, Lin CC, Fu SL. In vitro and in vivo anticancer activity of a synthetic glycolipid as TLR4 activator. J Biol Chem. 2011 Dec; 286(51): 43782-43792.
  1. Su NW, Leu YS, Lee JC, Chen YJ, Chen HW, Liu CJ, Chang YF. Comparison of the efficacy and toxicity of two dose levels of cisplatin/5-fluorouracil as the chemoradiotherapy regimen for the treatment of locally advanced squamous cell carcinoma of the head and neck. Acta Oto-Laryngol. 2011 Dec; 131(12): 1333-1340.
  1. Wu CJ, Wang YH, Lin CJ, Chen HH, Chen YJ*. Tetrandraine down-regulates ERK/NF-kB signaling and inhibits activation of mesangial cells. Toxicol In Vitro. 2011 Dec; 25(8): 1834-1840.
  1. Hsieh CH, Huang YC, Tsai TH, Chen YJ*. Cantharidin modulates development of human monocyte-derived dendritic cells. Toxicol In Vitro. 2011 Dec; 25(8): 1740-1747.
  1. Hsieh CH, Liao HF, Kuo CD, Huang YC, Shueng PW, Hsu YP, Wang LY, Tsai TH, Chen YJ*. Norcantharidin modulates development of dendritic cells and prolongs skin allograft survival. Transplantation. 2011 Oct; 92(8): 848-857.
  1. Chen YJ, Lin CP, Hsu ML, Shieh HR, Chao NK, Chao KSC. Sonic hedgehog signaling protects human hepatocellular carcinoma cells against ionizing radiation in an autocrine manner. Int J Radiat Oncol. 2011 Jul; 80(3): 851-859.
  1. Hsieh CH, Liu CY, Hsieh YJ, Tai HC, Wang LY, Tsai TH, Chen YJ*. Matrix metalloproteinase-8 mediates the unfavorable systemic impact of local irradiation on pharmacokinetics of anti-cancer drug 5-fluorouracil. PLoS One. 2011 Jun; 6(6): e21000.
  1. Hsieh CH, Chung SD, Chan PH, Lai SK, Chang HC, Hsiao CH, Wu LJ, Chong NS, Chen YJ, Wang LY, Hsieh YP, Shueng PW. Intensity modulated radiotherapy for elderly bladder cancer patients. Radiat Oncol. 2011 Jun; 6(1): 56.
  1. Liu CY, Chang HS, Chen IS, Chen CJ, Hsu ML, Fu SL, Chen YJ*. Costunolide causes mitotic arrest and enhances radiosensitivity in human hepatocellular carcinoma cells. Radiat Oncol. 2011 May; 6(1): 56.
  1. Cheng PC, Lin CN, Chen YJ, Chang FS, Tsaihong JC, Lee KM. Triggering receptor expressed on myeloid cells (TREM)-1 participates in Schistosoma mansoni inflammatory responses. Parasite Immunol. 2011 May; 33(5): 276-286.
  1. Wang CH, Liu CJ, Chien CC, Chen HT, Hua TE, Leng WH, Chen HH, Kempson IM, Hwu Y, Hsiao M, Lai TC, Wang JL, Yang CS, Lin HM, Chen YJ, Margaritondo G.. X-ray synthesized PEGylated (polyethylene glycol coated) gold nanoparticles in mice strongly accumulate in tumor. Mater Chem Phys. 2011 Mar 126(1-2): 352-356.
  1. Lai JCY, Chen JR, Chen YJ, Hsu CH, Wang TY, Yang YC, Su TH, Tsai TH, Wang KL. Villoglandular adenocarcinoma of the uterine cervix: an analysis of 12 clinical cases. Int J Gerontol. 2011 Mar; 5(1): 49-52.
  1. Liao HF, Chen YJ, Chou CH, Wang FW, Kuo CD. Norcantharidin induces cell cycle arrest and inhibits progression of human leukemic Jurkat T cells through mitogen-activated protein kinase-mediated regulation of interleukin-2 production. Toxicol In Vitro. 2011 Feb; 25(1): 206-212.
  1. Hsieh CH, Kuo YS, Liao LJ, Hu KY, Lin SC, Wu LJ, Lin YC, Chen YJ, Wang LY, Hsieh YP, Lin SL, Chen CY, Chen CA, Shueng PW. Image-guided intensity modulated radiotherapy with helical tomotherapy for postoperative treatment of high-risk oral cavity cancer. BMC Cancer 2011 Jan; 11: 37.
  1. Chen MJ, Chou CJ, Chang TT, Chen YJ*. Compound MMH02 possesses toxicity against human cancer cells with sparing of normal monocytes. Int J Gerontol. 2010 Dec; 4(4): 207-208.
  1. Liu HC, Chen YC, Chen CH, Chen YJ*. Esophagectomy in elderly patients with esophageal cancer. Int J Gerontol. 2010 Dec; 4(4): 176-179.
  1. Hsieh CH, Chang HT, Lin SC, Chen YJ, Wang LY, Hsieh YP, Chen CA, Chong NS, Lin SL, Chen CY, Shueng PW. Toxic risk of stereotactic body radiotherapy and concurrent helical tomotherapy followed by erlotinib for non-small- cell lung cancer treatment- case report. BMC Cancer. 2010 Dec; 10(1): 696.
  1. Chiang J, Chen YY, Akiko T, Huang YC, Hsu ML, Jang TR, Chen YJ*. Tai Chi Chuan increases circulating myeloid dendritic cells. Immunol Invest. 2010 39(8): 863-873.
  1. Cheng SP, Lee JJ, Chi CW, Chang KM, Chen YJ*. Platonin improves survival of skin allografts. J Surg Res. 2010 Nov; 164(1): 146-154.
  1. Hsieh CH, Wei MC, Hsu YP, Chong NS, Chen YJ, Hsiao SM, Hsieh YP, Wang LY, Shueng PW. Should helical tomotherapy replace brachytherapy for cervical cancer. BMC Cancer. 2010 Nov; 10(1): 637.
  1. Wang KL, Yang YC, Lai Jerry CY, Tsai TH, Lin CP, Wu YT, Chen YY, Wang SC, Chen YJ*. Comparison in purity and antitumor effect of brand and generic paclitaxel against human ovarian cancer cells by an in vitro experimental model. Drug Dev Ind Pharm. 2010 Oct; 36(10): 1253-1258.
  1. Huang YC, Shieh HR, Chen YJ*. Midostaurin (PKC412) modulates differentiation and maturation of human myeloid dendritic cells. Toxicol In Vitro. 2010 Sep; 24(6): 1705-1710.
  1. Hung SK, Hung LC, Kuo CD, Lee KY, Lee MS, Lin HY, Chen YJ, Fu SL. Andrographolide sensitizes ras-transformed cells to radiation in vitro and in vivo. Int J Radiat Oncol. 2010 Jul; 77(4): 1232-1239721.
  1. Shueng PW, Wu LJ, Chen SY, Hsiao CH, Tien HJ, Cheng PW, Kuo YS, Chen YJ, Chen CA, Hsieh PY, Hsieh CH. Concurrent chemoradiotherapy with helical tomotherapy for oropharyngeal cancer: a preliminary result. Int J Radiat Oncol. 2010 Jul; 77(3): 715-721.
  1. Hsieh KC, Chen YY, Jang TR, Chen YJ*. Middle-aged subjects with habitual low-speed cycling exercise have greater mononuclear cell responsiveness against human hepatitis B virus surface antigen. Int J Gerontol. 2010 Jun; 4(2): 82-88.
  1. Hsieh CH, Liu CY, Shueng PW, Chong NS, Chen CJ, Chen MJ, Lin CC, Wang TE, Lin SC, Tai HC, Tien HJ, Chen KH, Wang LY, Hsieh YP, Huang DY, Chen YJ*. Comparison of coplanar and noncoplanar intensity-modulated radiation therapy and helical tomotherapy for hepatocellular carcinoma. Radiat Oncol. 2010 May; 5: 40.
  1. Chang JTC, Lin CY, Lin JC, Lee MS, Chen YJ, Wang HM. Transdermal fentanyl for pain caused by radiotherapy in head and neck cancer patients treated in an outpatient setting: a multicenter trial in Taiwan. Jpn J Clin Oncol. 2010 Apr; 40(4): 307-312.
  1. Hsieh CH, Hsieh YJ, Liu CY, Tai HC, Huang YC, Shueng PW, Wu LJ, Tsai TH, Chen YJ*. Abdominal irradiation modulates 5-fluorouracil pharmacokinetics. J Transl Med. 2010 Mar; 8(1): 29.
  1. Chen YJ, Chen YY, Wu CT, Yu CC, Liao HF. Prolamin, a rice protein, augments anti-leukaemia in immune response. J Cereal Sci. 2010 Mar; 51(2): 189-197.
  1. Liu CJ, Wang CH, Chen ST, Chen HH, Leng WH, Chien CC, Wang CL, Kempson IM, Hwu Y, Lai TC, Hsiao M, Yang CS, Chen YJ, Margaritondo G. Enhancement of cell radiation sensitivity by pegylated gold nanoparticles. Phys Med Biol. 2010 Feb; 55(4): 931-945.
  1. Chen CA, Chang HH, Kao CY, Tsai TH, Chen YJ*. Plumbagin, isolated from Plumbago zeylanica, induces cell death through apoptosis in human pancreatic cancer cells. Pancreatology. 2009 9(6): 797-809.
  1. Shueng PW, Lin SC, Chang HT, Chong NS, Chen YJ, Wang LY, Hsieh YP, Hsieh CH. Toxicity risk of non-target organs at risk receiving low-dose radiation: case report. Radiat Oncol. 2009 Dec; 4: 71.
  1. Hsieh CH, Wei MC, Lee HY, Hsiao SM, Chen CA, Wang LY, Hiseh YP, Tsai TH, Chen YJ, Shueng PW. Whole pelvic helical tomotherapy for locally advanced cervical cancer: technical implementation of IMRT with helical tomography. Radiat Oncol. 2009 Dec; 4: 62.
  1. Chen YJ, Tsai YM, Kuo CD, Ku KL, Shie HS, Liao HF. Norcantharidin is a small-molecule synthetic compound with anti-angiogenesis effect. Life Sci. 2009 Oct; 85(17-18): 642-651.
  1. Chen YJ, Chang WM, Liu YW, Lee CY, Jang YH, Kuo CD, Liao HF. A small-molecule metastasis inhibitor, norcantharidin, downregulates matrix metalloproteinase-9 expression by inhibiting SP1 transcription activity in colorectal cancer cells. Chem-Biol Interact. 2009 Oct; 181(3): 440-446.
  1. Huang YC, Chao DK, Chao KS, Chen YJ*. Oral small-molecular tyrosine kinase inhibitor Midostaurin (PKC412) inhibits growth and induces megakaryocytic differentiation in human leukemia cells. Toxicol In Vitro. 2009 Sep; 23(6): 979-985.
  1. Chen YJ, Chao KS, Yang YC, Hsu ML, Lin CP, Chen YY. Zoledronic acid, an aminobisphosphonate, modulates differentiation and maturation of human dendritic cells. Immunopharmacol Immunotoxicol. 2009 Sep; 31(3): 499-508.
  1. Chen YJ, Huang AC, Chang HH, Liao HF, Jiang CM, Lai LY, Chan JT, Chen YY, Chiang J. Caffeic acid phenethyl ester, an antioxidant from Propolis, protects peripheral blood mononuclear cells of competitive cyclists against hyperthermal stress. J Food Sci. 2009 Aug; 74(6): H162-167.
  1. Chen YJ, Yu CC, Chen ST, Chen TY, Liao HF. Functional regulation and proteomic characterization of human natural killer cells through recombinant human granulocyte-cology stimulating factor treatment. Proteom Clin Appl. 2009 May; 3(5): 563-573.
  1. Yang YC, Chao KSC, Lin CP, Chen YY, Wang KL, Chen YJ*. Oxaliplatin regulates DNA repair responding to ionizing radiation and enhances radiosensitivity of human cervical cancer cells. Int J Gynecol Cancer. 2009 May; 19(4): 782-786.
  1. Chen YJ*, Chou CJ, Chang TT. Compound MMH01 possesses toxicity against human leukemia and pancreatic cancer cells. Toxicol in Vitro. 2009 Apr; 23(3): 418-424.
  1. Chiu SC, Lai YL, Chang HH, Chang KH, Chen ST, Liao HF, Chen YY, Chen YJ*. The therapeutic effect of modified Yu Ping Feng San on idiopathic sweating in end-stage cancer patients during hospice care. Phytother Res. 2009 Mar; 23(3): 363-366.
  1. Leu, YS. Chang YF, Lee JC, Liu CJ, Hsiao HT, Chen YJ, Chen HW, Lin YP. Squamous cell carcinoma of the oral cavity in the elderly. Int J Gerontol. 2009 Mar; 3(1): 75-80.
  1. Tai HC, Hsieh CH, Chao KSC, Liu SH, Leu YS, Chang YF, Hsiao HT, Chang YC, Huang DY, Chen YJ*. Comparison of radiotherapy strategies for locally advanced hypopharyngeal cancer after resection and ileocolic flap reconstruction. Acta Oto-Laryngol. 2009 Mar; 129(3): 311-317.
  1. Chen YJ, Huang WP, Yang YC, Lin CP, Chen SH, Hsu ML, Tseng YJ, Shieh HR, Chen YY, Lee JJ. Platonin induces autophagy-associated cell death in human leukemia cells. Autophagy. 2009 Feb; 5(2): 173-183.
  1. Hsieh CH, Jeng KS, Lin CC, Chen CK, Liu CY, Lin CP, Tai HC, Wang CH, Shueng PW, Chen YJ*. Combination of sorafenib and intensity modulated radiotherapy for unresectable hepatocellular carcinoma. Clin Drug Invest. 2009 Jan; 29(1): 65-71.
  1. Chen YY, Chiang J, Chen YJ, Chen KT, Yang RS, Lin JG. Cycling and Tai Chi Chuan exercises exert greater immunomodulatory effect on surface antigen expression of human hepatitis B virus. Chin Med J. 2008 Nov; 121(21): 2172-2179.
  1. Chen HW, Yang SF, Chang YC, Wang TY, Chen YJ, Hwang JJ. Epstein-Barr virus infection and plasma transforming growth factor-b1 levels in head and neck cancers. Acta Oto-Laryngol. 2008 Oct; 128(10): 1145-1151.
  1. Chen MJ, Chang WH, Lin CC, Liu CY, Wang TE, Chu CH, Shih SC, Chen YJ*. Caffeic acid phenethyl ester induces apoptosis of human pancreatic cancer cells involving caspase and mitochondrial dysfunction. Pancreatology. 2008 Oct; 8(6) 566-576.
  1. Huang GC, Chen LJ, Liu HC, Chen YJ*. Development of vitreous haemorrhage during treatment with bevacizumab for metastatic rectal cancer. Clin Drug Invest. 2008 Aug; 28(8):523-526.
  1. Liu CJ, Wang CH, Chien CC, Yang TY, Chen ST, Leng WH, Lee CF, Lee KH, Hwu Y, Lee YC, Cheng CL, Yang CS, Chen YJ, Je JH, Margaritondo G. Enhanced x-ray irradiation-induced cancer cell damage by gold nanoparticles treated by a new synthesis method of polyethylene glycol modification. Nanotechnology. 2008 Jul; 19(29): 295104 (5pp).
  1. Wang SL, Lin HT, Liang TW, Chen YJ, Yen YH, Guo SP. Reclamation of chitinous materials by bromelain for the preparation of antitumor and antifungal materials. Bioresource Technol. 2008 Jul; 99(10): 4386-4393.
  1. Liu CY, Chen YW, Cheng MJ, Lee SJ, Abd El-Razek MH, Chang WH, Chen YJ, Chen IS. Cytotoxic constituents from the root wood of formosan Michelia compressa. J Chil Chem Soc. 2008 Jun; 53(2): 1523-1524.
  1. Lin CC, Wang TE, Liu CY, Lin CP, Liu TP, Chen MJ, Chang WH, Lin JC, Chang KM, Chu CH, Shih SC, Chao KSC, Chen YJ*. Potentiation of the immunotherapeutic effect of autologous dendritic cells by pretreating hepatocellular carcinoma with low-dose radiation. Clin Invest Med. 2008 May; 31(3): E150-E159.
  1. ChenYJ, Cheng PC, Lin CN, Liao HF, Chen YY, Chen CC, Lee KM. Polysaccharides from Antrodia camphorata mycelia extracts possess immunomodulatory activity and inhibits infection of Schistosoma mansoni. Int Immunopharmacol. 2008 Mar; 8(3): 458-467.
  1. Hsieh YJ, Chang CH, Huang SP, Lin CW, Wang MN, Wu YT, Chen YJ, Tsai TH. Effect of cyclosporin A on the brain regional distribution of doxorubicin in rats. Int J Pharm. 2008 Feb; 350(1-2): 265-271.
  1. Chen YJ, Huang SM, Liu CY, Yeh PH, Tsai TH. Hepatobiliary excretion and enterohepatic circulation of colchicine in rats. Int J Pharm. 2008 Feb; 350(1-2): 230-239.
  1. Chen YJ, Kuo CD, Tsai YM, Yu CC, Wang GS, Liao HF. Norcantharidin induces anoikis through Jun-N-terminal kinase activation in CT26 colorectal cancer cells. Anti-Cancer Drug. 2008 Jan; 19(1): 55-64.
  1. Wang KL, Yang YC, Chao KSC, Wu MH, Tai HC, Chen TC, Huang MC, Chen JR, Su TH, Chen YJ*. Correlation of traditional point A with anatomic location of uterine artery and ureter in cancer of the uterine cervix. Int J Radiat Oncol. 2007 Oct; 69(2): 498-503.
  1. Liao HF, Su SL, Chen YJ, Chou CH, Kuo CD. Norcantharidin preferentially induces apoptosis in human leukemic Jurkat cells without affecting viability of normal blood mononuclear cells. Food Chem Toxicol. 2007 Sep; 45(9): 1678-1687.
  1. Chiang LM, Chen YJ, Chiang J, Lai LY, Chen YY, Liao HF. Modulation of dendritic cells by endurance training. Int J Sports Med. 2007 Sep; 28(9): 798-803.
  1. Chen YJ, Sims-Mourtada J, Izzo J, Chao KSC. Targeting the hedgehog pathway to mitigate treatment resistance. Cell Cycle. 2007 Aug; 6(15): 1826-1830.
  1. Chen YJ, Liao HF. NK/NKT cells and aging. Int J Gerontol. 2007 Jun; 1(2): 65-76.
  1. Liang TW, Chen YJ, Yen YH, Wang SL. The antitumor activity of the hydrolysates of chitinous materials hydrolyzed by crude enzyme from Bacillus amyloliquefaciens V656. Process Biochem. 2007 Apr; 42(4): 527-534.
  1. Liao HF, Yang YC, Chen YY, Hsu ML, Shieh HR, Chen YJ*. Macrophages derived from bone marrow modulate differentiation of myeloid dendritic cells. Cell Mol Life Sci. 2007 Jan; 64(1): 104-111.
  1. Liu HC, Chen YJ, Tzen CY, Huang CJ, Chang CC, Huang WC. Debulking surgery for advanced thymoma. EJSO-Eur J Surg Onc. 2006 Nov; 32(9): 1000-1005.
  1. Wang SL, Lin TY, Yen YH, Liao HF, Chen YJ. Bioconversion of shellfish chitin wastes for the production of Bacillus subtilis W-118 chitinase. Carbohyd Res. 2006 Nov; 341(15): 2507-2515.
  1. Liao HF, Chen YY, Yang YC, Wang CS, Chen YJ*. Rice (Oryza sativa L.) inhibits growth and induces differentiation of human leukemic U937 cells through activation of peripheral blood mononuclear cells. Food Chem Toxicol. 2006 Oct; 44(10): 1724-1729.
  1. Hsieh CH, Chen YJ, Chang KH, Hsu HH, Liu CK, Hung SK, Chen HW, Lai YL, Hsu TC. Post-operative concurrent chemoradiation therapy using oral uracil-tegafur versus weekly intravenous fluorouracil for locally advanced rectal cancer. Anticancer Res. 2006 Sep-Oct; 26(5B): 3709-3715.
  1. Yang YC, Wang KL, Su TH, Liao HF, Wu MH, Chen TC, Huang MC, Chen YJ*. Concurrent cisplatin-based chemoradiation for cervical carcinoma: Tumor response, toxicity, and serum cytokine profiles. Cancer Invest. 2006 Jun-Jul; 24(4): 390-395.
  1. Liao HF, Chiang LM, Yen CC, Chen YY, Zhuang RR, Lai LY, Chiang J, Chen YJ*. Effect of a periodized exercise training and active recovery program on antitumor activity and development of dendritic cells. J Sport Med Phys Fit. 2006 Jun; 46(2): 307-314.
  1. Wu CJ, Sheu JR, Chen HH, Liao HF, Yang YC, Yang S, Chen YJ*. Modulation of monocyte-derived dendritic cell differentiation is associated with ischemic acute renal failure. J Surg Res. 2006 May; 132(1): 104-111.
  1. Lee JJ, Liao HF, Yang YC, Liu CL, Chen YY, Lin CP, Chen YC*. Platonin modulates differentiation and maturation of human monocyte-derived dendritic cells. Int Immunopharmacol. 2006 Feb; 6(2): 287-293.
  1. Wu CJ, Sheu JR, Chen HH, Liao HF, Yang YC, Yang S, Chen YJ*. Renal ischemia/reperfusion injury inhibits differentiation of dendritic cells derived from bone marrow monocytes in rats. Life Sci. 2006 Feb; 78(10): 1121-1128.
  1. Liao HF, Kuo CD, Yang YC, Lin CP, Tai HC, Chen YY, Chen YJ*. Resveratrol enhances radiosensitivity of human non-small cell lung cancer NCI-H838 cells accompanied by inhibition of nuclear factor-kappa B activation. J Radiat Res. 2005 Dec; 46(4): 387-393.
  1. Chen YJ, Liao HF, Tsai TH, Wang SY, Shiao MS. Caffeic acid phenethyl ester preferentially sensitizes CT26 colorectal adenocarcinoma to ionizing radiation without affecting bone marrow radioresponse. Int J Radiat Oncol. 2005 Nov; 63(4): 1252-1261.
  1. Liu HC, Hung SK, Huang CJ, Chen CC, Chen MJ, Chang CC, Tai CJ, Tzen CY, Lu LH, Chen YJ*. Esophagectomy for locally advanced esophageal cancer, followed by chemoradiotherapy and adjuvant chemotherapy. World J Gastroenterol. 2005 Sep; 11(34): 5367-5372.
  1. Liu CY, Liao HF, Wang TE, Lin SC, Shih SC, Chang WH, Yang YC, Lin CC, Chen YJ*. Etoposide sensitizes CT26 colorectal adenocarcinoma to radiation therapy in BALB/c mice. World J Gastroenterol. 2005 Aug; 11(31): 4895-4898.
  1. Chen HW, Chang YC, Lai YL, Chen YJ, Huang MJ, Leu YS, Fu YK, Wang LW, Hwang JJ. Change of plasma transforming growth factor –b1 levels in nasopharyngeal carcinoma patients treated with concurrent chemo-radiotherapy. Jpn J Clin Oncol. 2005 Aug; 35(8): 427-432.
  1. Liu CY, Liao HF, Shih SC, Lin SC, Chang WH, Chu CH, Wang TE, Chen YJ*. Colchicine sensitizes human hepatocellular carcinoma cells to damages caused by radiation. World J Gastroenterol. 2005 Jul; 11(27): 4237-4240.
  1. Leu YS, Hsiao HT, Chang YC, Yang CC, Lee JC, Chen YJ, Chang YF. Ileocolic free flap reconstruction, concomitant chemotherapy and radiotherapy and assessment of speech and swallowing function during management of advanced cancer of the larynx and hypopharynx: preliminary report. Acta Oto-Laryngol. 2005 Jun; 125(6): 642-646.
  1. Liao HF, Chen YJ, Yang YC. A novel polysaccharide of black soybean promotes myelopoiesis and reconstitutes bone marrow after 5-flurouracil- and irradiation-induced myelosuppression. Life Sci. 2005 Jun; 77(4): 400-413.
  1. Chen YJ, Shieh CJ, Tsai TH, Kuo CD, Ho LT, Liu TY, Liao HF. Inhibitory effect of norcantharidin, a derivative compound from blister beetles, on tumor invasion and metastasis in CT26 colorectal adenocarcinoma cells. Anti-Cancer Drug. 2005 Mar; 16(3): 293-299.
  1. Huang HL, Wu SL, Liao HF, Jiang CM, Huang RL, Chen YY, Yang YC, Chen YJ*. Induction of apoptosis by three marine algae through generation of reactive oxygen species in human leukemic cell lines. J Agr Food Chem. 2005 Mar; 53(5): 1776-1781.
  1. Liao HF, Shyu SY, Kuo YH, Yang YC, Chen YJ*. Compound 278E, structurally modified from tanshinone, induces monocytic differentiation and regulates protooncogene expression in human leukemic HL-60 cells. Anti-Cancer Drug. 2005 Feb; 16(2): 175-183.
  1. Ou HT, Shieh CJ, Chen JY, Chang HM. The antiproliferative and differentiating effects of human leukemic U937 cells are mediated by cytokines from activated mononuclear cells by dietary mushrooms. J Agr Food Chem. 2005 Jan; 53(2): 300-305.
  1. Chang KH, Liao HF, Chang HH, Chen YY, Yu MC, Chou CJ, Chen YJ*. Inhibitory effect of tetrandrine on pulmonary metastases in CT26 colorectal adenocarcinoma-bearing BALB/c mice. Am J Chinese Med. 2004 Dec; 32(6): 863-872.
  1. Chen MF, Wu CT, Chen YJ, Keng PC, Chen WC. Cell killing and radiosensitization by caffeic acid phenethyl ester (CAPE) in lung cancer cells. J Radiat Res. 2004 Jun; 45(2): 253-260.
  1. Liao HF, Chen YY, Liu JJ, Hsu ML, Shieh HJ, Liao HJ, Shieh CJ, Shiao MS, Chen YJ*. Inhibitory effect of caffeic acid phenethyl ester on angiogenesis, tumor invasion, and metastasis. J Agr Food Chem. 2003 Dec; 51(27): 7907-7912.
  1. Lai YL, Chang HH, Huang MJ, Chang KH, Su WH, Chen HW, Chung CH, Wang WY, Lin LH, Chen YJ*. Combined effect of topical arsenic trioxide and radiation therapy on skin-infiltrating lesions of breast cancer-a pilot study. Anti-Cancer Drug. 2003 Nov; 14(10): 825-828.
  1. Wu CJ, Sheu JR, Chen HH, Shyur SD, Chen PG, Chen YJ*. Anti-leukemic immunity against U937 cells in uremic patients. Neoplasma. 2003 50(1): 54-59.
  1. Chen YJ. Potential role of tetrandrine in cancer therapy. Acta Pharmacol Sin. 2002 Dec; 23(12): 1102-1106.
  1. Liu HC, Hsu WH, Chen YJ, Chan YJ, Wu YC, Huang BS, Huang MS. Primary thymic carcinoma. Ann Thorac Surg. 2002 Apr; 73(4): 1076-1081.
  1. Chung CC, Chiang J, Chiang CM, Chen YY, Huang CY, Chen PG, Chen YJ. Basic fibroblast growth factor as a growth factor for SRV-2-infected simian retroperitoneal fibromatosis cells, an animal model for AMS related Kaposi’s sarcoma. Neoplasma. 2001 48(3): 192-199.
  1. Chen YJ, Shiao MS, Hsu ML, Tsai TH, Wang SY. Effect of caffeic acid phenethyl ester, an antioxidant from propolis, on inducing apoptosis in human leukemic HL-60 cells. J Agr Food Chem. 2001 Nov; 49(11): 5615-5619.
  1. Chen YJ, Shiao MS, Wang SY. The antioxidant caffeic acid phenethyl ester induces apoptosis associated with selective scavenging of hydrogen peroxide in human leukemic HL-60 cells. Anti-Cancer Drug. 2001 Feb; 12(2): 143-149.
  1. Chiang J, Huang YW, Chen ML, Wang SY, Huang AC, Chen YJ. Comparison of anti-leukemic immunity against U937 cells in endurance athletes versus sedentary controls. Int J Sports Med. 2000 Nov; 21(8): 602-607.
  1. Chen YJ, Shyur SD, Wang CY, Huang KY, Chao YK, Chen PG. Comparison of antileukemic immunity against U937 cells in atopic asthmatics versus healthy controls. Neoplasma. 1999 46(5): 304-308.
  1. Chang KH, Chen ML, Chen HC, Huang YW, Wu TY, Chen YJ. Enhancement of radiosensitivity in hman glioblastoma U138MG cells by tetradrine. Neoplasma. 1999 46(3): 196-200.
  1. Chen YJ, Dai YS, Chen BF, Chang A, Chen HC, Lin YC, Chang KH, Lai YL, Chung CH, Lai YJ. The effect of tetrandrine and extracts of Centella asiatica on acute radiation dermatitis in rats. Biol Pharm Bull. 1999 Jul; 22(7): 703-706.
  1. Lai YL, Chen YJ, Wu TY, Wang SY, Chang KH, Chung CH, Chen ML. Induction of apoptosis in human leukemic U937 cells by tetrandrine. Anti-Cancer Drug. 1998 Jan; 9(1): 77-81.
  1. Chen YJ, Tu ML, Kuo HC, Chang KH, Lai YL, Chung CH, Chen ML. Protective effect of tetrandrine on normal human mononuclear cells against ionizing irradiation. Biol Pharm Bull. 1997 Nov; 20(11): 1160-1164.
  1. Chen YJ, Shiao MS, Lee SS, Wang SY. Effect of Cordyceps sinensis on the proliferation and differentiation of human leukemic U937 cells. Life Sci. 1997 May; 60(25) 2349-2359.

 

Non-SCI papers:

  1. Cheng CY, Liu CJ, Huang CY, Wu SH, Fang HW, Chen YJ*. BI2536 induces mitotic catastrophe and radiosensitization in human oral cancer cells. OncoTarget. 2018 Apr 9(30): 21231-21243.
  1. Huang YC, Liao WL, Lin JM, Chen CC, Liu SP, Chen SY, Lin YN, Lei YJ, Liu HT, Chen YJ*, Tsai FJ. High levels of circulating endothelial progenitor cells in patients with diabetic retinopathy are positively associated with ARHGAP22 expression. OncoTarget. 2018 Apr; 9(25): 17858-17866.
  1. Chang WH, Hsieh CH, Chen YJ, Wang LY. Effect of off-target low dose radiation on myocardial contractile function-an animal study. Formosan J of Phy Ther. 2017 Dec; 42(4): 339-340.
  1. Chen ST, Lee TY, Tsai TH, Huang YC, Lin YC, Lin CP, Shieh HR, Hsu ML, Chi CW, Lee MC, Chang HH, Chen YJ*. Traditional Chinese medicine Danggui Buxue Tang inhibits colorectal cancer growth through induction of autophagic cell death. OncoTarget. 2017 Oct; 8(51): 88563-8857
  1. Dai KY, Huang WC, Leu YS, Tsai CH, Chan ML, Lin HC, Su NW, Chen YJ*. Preliminary results of preoperative chemoradiation therapy for cervical esophageal squamous cell carcinoma with larynx preservation. Therapeut Radiol Oncol. 2016 Dec; 23(4): 237-247.
  1. Chang WH, Huang HL, Huang WP, Chen CC, Chen YJ*. Armillaridin induces autophagy-associated cell death in human chronic myelogenous leukemia K562 cells. Tumour Biol. 2016 Oct; 37(10): 14291-14300.
  1. Lu KW, Lee J, Tsai XZ, Chen YJ, Wu MH. Comparison of dosimetry for left anterior descending coronary artery in left breast irradiation by intensity-modulated and 3-dimentional conformal radiotherapy. Therapeut Radiol Oncol. 2016 Sep; 22(3): 171-185.
  1. Huang WC, Chan ML, Chen MJ, Tsai TH, Chen YJ*. Modulation of macrophage polarization and lung cancer cell stemness by MUC1 and development of a related small-molecule inhibitor pterostilbene. OncoTarget. 2016 Jun; 7(26): 39363-39375.
  1. Huang HN, Huang GC, Liu HC, Chang YF, Chen YJ*. Tracheal adenoid cyctic carcinoma: post-operative chemoradiotherapy- a case report. Therapeut Radiol Oncol. 2016 Mar; 23(1): 77-83.
  1. Fu SL, Lin CC, Hsu ML, Liu SH, Huang YC, Chen YJ*. CCL-34, a synthetic toll-like receptor 4 activator, modulates differentiation and maturation of myeloid dendritic cells. OncoTarget. 2016 Mar; 7(10): 11677-11686.
  1. Huang HN, Yang PS, Dai HC, Chen YJ*. IntraoperatIve radiotherapy of extrahepatIc cholangiocarcinoma- a case report. Therapeut Radiol Oncol. 2015 Dec; 22(4): 315-321.
  1. Chien L, Chen WK, Liu ST, Chang CR, Kap MC, Chen KW, Chiu SC, Hsu ML, Hsiang IC, Chen YJ*, Chen L. Low-dose ionizing radiation induces mitochondrial fusion and increases expression of mitochondrial complexes I and III in hippocampal neurons. OncoTarget. 2015 Oct; 6(31): 30628-30639.
  1. Lee J, Lu KW, Fu HM, Dai KY, Chen YJ, Wu MH. Evaluation of dose to heart and left anterior descending coronary artery during left breast irradiation. Therapeut Radiol Oncol. 2015 Mar 22(1): 13-23.
  1. Chia PS, Fu HM, Dai KY, Leu YS, Wu MH, Tai HC, Chen YJ*. Application of a spacer medial to the left parotid gland toimprove dosimetry for head and neck radiotherapy-A swine model. Therapeut Radiol Oncol. 2014 Dec 21(4): 285-294.
  1. Wang YF, Chang CJ, Chiu JH, Lin CP, Li WY, Chang SY, Chu PY, Tai SK, Chen YJ*. NM23-H1 expression of head and neck squamous cell carcinoma in association with the response to cisplatin treatment. OncoTarget. 2014 Sep; 5(17): 7392-7405.
  1. Chen YJ, Chi CW, Su WC, Huang HL. Lapatinib induces autophagic cell death and inhibits growth of human hepatocellular carcinoma. OncoTarget. 2014 Jul; 5(13): 4845-4854.
  1. LeuYS, Chang YF, Lee JC, Hsiao HT, Chen YJ, Chen HW, Sun FJ. The impact on survival after change of treatment modalities in advanced hypopharyngeal cancer. J Taiwan Oto-Laryngol Head & Neck Surg. 2013 Mar 48(1): 87-96.
  1. Chen WK, Chang KH, Liu HC, Wang TY, Wu MH, Chen YJ*. Adjuvant radiotherapy for malignant solitary fibrous tumor of the pleura- a case report. Therapeut Radiol Oncol. 2012 Sep 19(2): 247-254.
  1. Chen JCH, Wang CH, Huang GC, Lin IC, Chen WK, Chia PS, Wu MH, Chen YJ* A novel vagina enhancement modality improves dosimetric parameters in pelvic intensity- modulated radiotherapy. Therapeut Radiol Oncol. 2011 Dec 18(4): 341-345.
  1. Hsieh CH, Chen YJ, Liu SH, Tien HJ, Wu LJ, Chen Liao LJ, Lin YC, Shueng PW. Helical tomotherapy reduces pain efficiently for circuited pleural metastasis of nasopharyngeal carcinoma- a case report. Therapeut Radiol Oncol. 2011 Dec 18(4): 311-319.
  1. Liu CY, Lai YL, Lin CP, Wu YT, Tsai TH, Chen YJ*. Anti-tumor effect of Archidendron lucidum (Benth.) against esophageal cancer, colorectal cancer and hepatoma. J Med Plamts Res. 2011 Oct 5(21): 5221-5229.
  1. Chen WK, Wang CH, Wu MH, Chao KSC, Huang D, ChenYJ*. Dosimetric analysis for sparing the obturator nerves using IMRT technique for cervical cancer. Therapeut Radiol Oncol. 2011 Jun; 18(2): 125-135.
  1. Takafuji A, Chen YJ, Chianf J. Effect of Tai Chi Chuan exercise on the growth and development of dendritri cell in middle-aged people. J of Phy Edu Sports Sci. 2011 Jun; 12: 1-8.
  1. Takafuji A, Chen YJ, Chianf J. Metabolic and physiological responses during Tai Chi Chuan exercise in middle-aged people. Sports Coaching Science 2010 Dec; 20: 21-32.
  1. Hung HC, Chen HW, Chang YF, Yang YC, Liu CL, Hsieh RK, Leu YS, Chen YJ, Wang TE, Tsai LY, Liu SI, Fang CK. Evaluation of the reliability and validity of the mandarin version of demoralization scale for cancer patients. J Intern Med Taiwan. 2010 Dec; 21(6): 427-435.
  1. Chang CW, Lin CC, Chang WH, Lin SC, Shih SC, Chan YJ, Chen YJ. Metastatic squamous cell carcinomaof the jejunum: report of a case. Gastroenterol J Taiwan. 2010 Jun; 27(2): 201-204.
  1. Chiou TJ, Liu CY, Tzeng WF, Su YC, Weng YC, Hung CJ, Tang Y, Chen YJ, Taiwan Cancer Pain Study Group. The use of transdermal fentanyl in cancer pain- a compliance study of outpatients in Taiwan. Am J Hosp Palliat Med. 2010 Feb; 27(1): 31-37.
  1. Chang YF, Lin YP, Su NW, Leu YS, Chen YJ, Liu CJ. Docetaxel, cisplatin and 5-fluorouracil in patients with refractory, recurrent, or metastatic squamous cell carcinoma of the head and neck. J Chinese Onc Soc. 2009 Oct; 25(5): 336-344.
  1. Chen YC, Liu SH, Lee JC, Wang TY, Tsai HC, Chen YJ*. Targeted the target volume? -a case report of laryngeal radionecrosis after conformal radiotherapy for early glottic carcinoma. Therapeut Radiol Oncol. 2009 Sep; 16(3): 235-241.
  1. Yen TY, Lin CC, Wang TY, Hsueh C, Hsu JM. Chen YJ*. Combination of induction chemotherapy, preoperative chemoradiation and surgery for locally advanced gastric cancer- a case with long-term control and testicular metastasis. Therapeut Radiol Oncol. 2009 Sep; 16(3): 227-234.
  1. Chen YJ*, Wang YF, Chao KSC. Caner stem cells and sonic hedgehog signaling in head and neck cancer. Potential targets for overcoming chemoradiation resistance. J Chinese Oncol Soc. 2009 Apr; 25(2): 81-88.
  1. Wu MH, Chen YJ. Glutamine supplementation for prevention of concurrent chemradiotherapy-induced acute diarrhea in cervical cancer patients. J Chinese Oncol Soc. 2009 Apr; 25(2): 123-131.
  1. Liu SH, Chen YJ*. Postoperative intensity modulated radiation therapy in oral cavity cancer. J Chinese Oncol Soc. 2009 Feb; 25(1): 12-19.
  1. Chen HW, Chen YJ, Leu YS, Liu CJ, Chang YF, Fang CK, Liu HC, Lai YL. A good ending-holistic care for patients with head and neck cancers. J Chinese Oncol Soc. 2009 Feb; 25(1): 20-27.
  1. Chen HD, Chang WH, Jeng KS, Chen YJ, Lin HC, Shi SC, Chen YJ. Ampullary adenocarcinoma presenting with acute pancreatitis and anemia. J Chinese Oncol Soc. 2009 Feb; 25(1): 52-58.
  1. Lee JC, Leu YS, Lee JC, Chang YF, Huang MJ, Chen YJ, Chen HW. Concurrent chemoradiotherapy using cisplatin and 5-fluorouracil alone or with paclitaxel followed by adjuvant cisplatin and 5-fluorouracil in nasopharyngeal carcinoma. J Chinese Oncol Soc. 2008 Dec; 24(6): 372-379.
  1. Wang SL, Tsai HC, Li YL, Chen FH, Tai HC, Chang KH, Chen YJ*. Compare the treatments with conventional 2-D radiotherapy combine with 3-D conformal therapy and intensity modulated radiation therapy (IMRT) dose distribution to nasopharyngeal carcinoma. C J Radiologic Tech. 2008 Dec; 32(12):181-190.
  1. Huang GC, Huang CJ, Chang KH, Chen YJ*. Adenoid cystic carcinoma of the trachea treated with post-operative chemoradiotherapy and metronomic chemotherapy: a case report. Therapeut Radiol Oncol. 2008 Dec; 15(4): 337-342.
  1. Wu MF, Leu YS, Lee JC, Hsiao HT, Chang YC, Yang CC, Chen YJ, Chang YF. Comparative analysis of treatment result in advanced hypopharyngeal cancer: chemoradiotherapy alone or surgery followed by chemoradiotherapy. J Chinese Oncol Soc. 2008 Nov; 24(4): 236-242.
  1. Yang CY, Leu YS, Lee JC, Chang YF, Huang MJ, Chen YJ, Chen HW, Hsiao HT, Liu CJ. Treatment outcome in oropharyngeal carcinoma-preliminary report. J Chinese Oncol Soc. 2008 Mar; 24(1): 10-16.
  1. Li MH, Liu YC, Chen YJ, Li YW, Chang KH. Three-dimensional conformal radiotherapy with or without oral thalidomide for advanced hepatocellular carcinoma. Therapeut Radiol Oncol. 2007 Jun; 14(2): 83-93.
  1. Hsieh CH, Hsu TC, Chen YJ, Hsu HH, Liu CK, Hung SK, Lai YL, Chen HW, Chang KH. Adjuvant concurrent uracil-tegafur with leucovorin and radiotherapy for locally advanced rectal cancer. Therapeut Radiol Oncol. 2006 Jun; 13(2): 117-125.
  1. Chen CA, Hsieh CH, Lai YL, Lee MS, Chen YJ, Hung SK. Side effects of amifostine with concurrent chemoradiation therapy for head and neck cancer. Therapeut Radiol Oncol. 2006 Jun; 13(2): 127-133.
  1. Hung SK, Chen HL, Hsieh CH, Hsu WL, Chang KH, Chen YJ, Lee MS. Concurrent chemoradiotherapy versus radiotherapy alone for hypopharyngeal cancer. Chin J Radiol. 2006 Apr; 31(2):77-84.
  1. Hung SK, Chen HL, Hsieh CH, Hsu WL, Chang KH, Liu DW, Chen YJ, Lee MS. Treatment of advanced hypopharyngeal cancer –comparison of two modalities. Tzu Chi Med J. 2006 Feb; 18(1): 15-21.
  1. Su WH, Lai YL, Chen YJ, Chang KH. Palliative splenic irradiation for splenomegaly: retrospective review of experience at the Mackay Memorial Hospital. Therapeut Radiol Oncol. 2005 Dec; 12(4): 277-283.
  1. Hung SK, Hsu WL, Chang KH, Liu HC, Liu DW, Sheng CH, Chen YJ, Lee MS. Benefit of postoperative multimodality therapy in patients with locally advanced esophageal cancer. Tzu Chi Med J. 2005 Oct; 17(5): 311-317.
  1. Liu SH, Chen YJ, Chang KH, Leu YS, Lee JC, Huang MJ, Chen HW, Lai YL. The effect and safety of transdermal fentanyl for concurrent chemoradiation therapy-induced mucositis pain in head and neck cancer patients. Therapeut Radiol Oncol. 2005 Jun; 12(2): 103-111.
  1. Hsieh CH, Chang KH, Chen YJ, Su WH, Hung SK, Lai YL. Amifostine and concurrent chemoradiation therapy for head and neck cancer-Mackay Memorial Hospital. The Journal of Health Science. 2005 Apr; 7(2): 121-128.
  1. Chang KH, Hung SK, Liu HC, Huang CJ, Lai YL, Chen YJ*. Surgery followed by concurrent chemoradiation with weekly cisplatin and adjuvant systemic chemotherapy for locally advanced esophageal cancer-a pilot study. Therapeut Radiol Oncol. 2005 Mar; 12(1): 9-16.
  1. Chen CA, Chang KH, Leu YS, Lee JC, Lai YL, Chen EJ, Chung CH, Chen YJ*. Concurrent weekly cisplatin and radiotherapy plus adjuvant chemotherapy for nasopharyngeal cancer-a preliminary study. Therapeut Radiol Oncol. 2004 Mar; 11(1): 9-15.
  1. Liu YC, Chen YJ, Lu YC, Chung CH. Recurrent pigmented villonodular synovitis of knee treated with surgery and adjuvant radiotherapy: a case report. Therapeut Radiol Oncol. 2004 Mar; 11(1): 55-58.
  1. Hung SK, Liu HC, Chang KH, Lai YL, Huang CJ, Chen YJ*. Concurrent chemoradiation with weekly cisplatin plus systemic adjuvant chemotherapy for locally advanced esophageal cancer: a pilot study. Therapeut Radiol Oncol. 2003 Dec; 10(4): 229-236.
  1. Chang AA, Chen HY, Tai HC, Huang D, Lai YL, Chen YJ*. Dose calculation for tissue inhomogeneity in lung cancer based on 6 mv photon beams. Therapeut Radiol Oncol. 2003 Sep; 10(3): 159-166.
  1. Chen ST, Chang KH, Chen YJ, Chung CH, Wu MH, Su WH, Chen HW, Lai YL. A double blinded, placebo-controlled study to evaluate the subjective efficacy. Therapeut Radiol Oncol. 2003 Mar; 10(1): 11-18.
  1. Chen HW, Lai YL, Chang KH, Chen YJ, Chung CH, Wu MH, Wang MC, Chiu SC. Single dose versus fractionated palliative radiotherapy of bone metastases: a prospective randomized trial. Therapeut Radiol Oncol. 1999 Dec; 6(4): 239-245.
  1. Chen HW, Lai YL, Chang KH, Chung CH, Wu MH, Wang MC, Chen YJ, Huang HC, Lu YT. The therapeutic effect of limited-field radiotherapy on immature teratoma of brainstem-a case report. Therapeut Radiol Oncol. 1999 Jun; 6(2): 149-154.
  1. Chen YJ, Shyur SD, Chang A, Chen HC, Chang KH, Lai YL, Chen PG. The combined effect of colchicine and radiation of human hepatoma HA22T/VGH cells. Therapeut Radiol Oncol. 1999 Jun; 6(2): 83-87.
  1. Chen YJ, Lo KY, Tzen CY, Huang RD, Chang KH, Lai YL, Chen ML. Relationship of bcl-2 and pp125(FAK) expression to outcome of radiation therapy in prostate carcinoma. J Tumor Marker Oncol. 1999 14(3): 19-24.
  1. Chen MF, Chen YJ, Lai YL, Shin BF, Chang KH, Chung CH. The prognosis significance of serum tumor marker in breast cancer. J Tumor Marker Oncol. 1999 14(1): 19-25.
  1. Chiu SC, Chang KH, Chen YJ, Chung CH, Lai YL, Wu MH. The role of radiotherapy for advanced non-small cell lung cancer. Therapeut Radiol Oncol. 1998 Dec; 5(4): 277-283.
  1. Wang MC, Leu YS, Chang KH, Lai YL, Chung CH, Wu MH, Chen YJ*. Comparison of clinical outcome in hypopharyngeal cancer treated with radiotherapy alone or surgery combined with adjuvant radiotherapy-10 years, experience in Mackay Memorial Hospital. Therapeut Radiol Oncol. 1998 Dec; 5(4): 253-259.
  1. Dai YS, Chen ML, Huang ZD, Tzen CY, Chang KH, Lai YL, Chung CH, Wu MH, Chen YJ*. Relationship of CD44 and bcl-2 expression to nodal radiation resistance in non-Hodgkin’s lymphoma. Therapeut Radiol Oncol. 1997 Dec; 4(4): 259-264.
  1. Wang MC, Wu MH, Chang KH, Lai YL, Chung CH, Liu TW, Chen YJ. Treatment result and prognostic factor in early stage endometrial carcinoma. Therapeut Radiol Oncol. 1997 Mar; 4(1): 17-22.
  1. Tsai JT, Lai YL, Yeh CY, Chen YJ, Shau WY, Chung CH, Chang KH. Prognostic parameters in malignant gliomas. Therapeut Radiol Oncol. 1996 Mar; 3(1): 49-61.
  1. Dai YS, Lai YL, Chung CH, Chang KH, Chen YJ, Shau WY, Hwang JY. Radiation therapy for pituitary adenoma. Therapeut Radiol Oncol. 1996 Mar; 3(1): 41-47.

 

專書(出版著作)

  1. Chen YJ, Liao HF, Chao C. Hedgehog Signaling and Cancer Treatment Resistance (Ch. 10), Hedgehog signaling activation in human cancer and its clinical implications, Springer, 201
  2. 分子輻射生物學第三章：細胞存活曲線；及第四章：有絲分裂週期的輻射敏感度和細胞分期之關係、陳裕仁編譯、國立編譯館暨藝軒圖書出版社合作翻譯發行、2008年12月第一版。
  3. 藥理學十日速成第28章：強心配醣體­毛地黃；及第31章：降血壓藥物、陳裕仁著、合計圖書出版社、2004年11月10日初版第12刷(修定版)。

 

專利

  1. 中華民國發明專利：去甲斑蝥酸二鈉於調控人類樹突細胞之用途，專利號碼：I472326，專利期限：2033/4/22。
  2. 中華民國發明專利：單離自金剛纂之化合物於癌症和／或血小板數量低下之治療用途，專利號碼：I463985，專利期限：2032/8/28。
  3. 美國發明專利：Method for inhibition tumor cell growth using (22R)-5a-lanosta-8,24-dien-3b, 15a, 21-triol，專利號碼：US8546366，專利期限：2032/5/30。
  4. 美國發明專利：Use of compounds isolated from Euphorbia neriifolia for treating cancer and/or thrombocytopenia，專利號碼：US8846768，專利期限：2032/4/27。
  5. 日本發明專利：?????位置????????????????放射線治療????，專利號碼：JP5497084，專利期限：2032/2/28。
  6. 美國發明專利：Novel use of amillaridin for treating cancer，專利號碼：US8663711B2，專利期限：2032/1/3。
  7. 中華民國發明專利：以密環菌乙素來治療癌症之新穎用途，專利號碼：I434829，專利期限：2032/1/1。
  8. 中華民國發明專利：即時監測標靶位置之放射治療系統，專利號碼：I454246，專利期限：2031/9/29。
  9. 美國發明專利：Use of isothiocyanates for treating cancer，專利號碼：US8691870，專利期限：2031/9/23。
  10. 中華民國發明專利：使用異硫氰酸酯類來治療癌症之方法及用途，專利號碼：I406658，專利期限：2031/9/18。
  11. 中華民國發明專利：羊毛甾醇-8.24-二烯-3β，15α，21-三醇抑制腫瘤細胞生長之用途，專利號碼：I444189，專利期限：2031/5/31。
  12. 日本發明專利：米???????白血病抑制???用，專利號碼：JP5497084，專利期限：2032/2/28
  13. 中華民國發明專利：稻米醇溶蛋白於抑制白血病之應用，專利號碼：I411442，專利期限：2030/1/28。
  14. 中華民國發明專利：利用牛樟芝萃取物去氫硫色多孔菌酸(dehydrosulphureic acid)以抑制腫瘤細胞生長之用途，專利號碼：I363631，專利期限：2028/6/17。
  15. 美國發明專利：METHOD FOR INHIBITING TUMOR GROWTH WITH DEHYDROSULPHURENIC ACID EXTRACTED FROM ANTRODIA CINNAMOMEA，專利號碼：7994158，專利期限：2028/11/5。
  16. 中華民國發明專利：結合放射線療法用於治療皮膚轉移性癌的含砷醫藥組成物，專利號碼：I335229，專利期限：2024/4/29。
  17. 中華民國新型專利：放射線劑量計之載具，專利號碼：M462608，專利期限：2019/4/1。

 

論文內容

  1. Find novel radiosensitizers for radiation-resistant tumor cells and radioprotectors for normal tissues.
  2. Targeting the hedgehog pathway to mitigate chemoradiation resistance.
  3. Pharmacological activity of natural products, especially norcantharidin, CAPE, plumbagin, nanoparticle, tetrandrine, platonin, MMH01 and MMH02 on inducing tumor cell redox imbalance, apoptosis, inhibiting angiogenesis, preventing metastasis, and autophagy.
  4. Pharmocokinetics of anti-cancer drugs, including absorption, distribution, metabolism and excretion. Applied the patents of potential anti-cancer drugs. The USA patent for MMH01 has been approved.
  5. Clinical research on radiotherapy.
  6. Induce differentiation and/or inhibit proliferation of human leukemic cells by natural products.
  7. Evaluate the effect of natural products, renal ischemia/reperfusion injury and exercise/training on dendritic cell differentiation and maturation as well as anti-leukemic immunity.
  8. Immunobiology of macrophages, dendritic cells and natural killer cells.
  9. The immunomodulatory interaction between Tai Chi Chuan and hepatitis.
  10. Epithelial progenitor cells analysis platform for translational research.